Behavioral Genetics of the Mouse : Volume 1, Genetics of Behavioral Phenotypes.

A comprehensive review of the current state of our knowledge on the inheritance of normal behaviour in the laboratory mouse.

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Bibliographic Details
Main Author: Crusio, Wim E.
Other Authors: Sluyter, Frans., Gerlai, Robert T., Pietropaolo, Susanna.
Format: eBook
Language:English
Published: New York : Cambridge University Press, 2013.
Series:Cambridge Handbooks in Behavioral Genetics
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100 1 |a Crusio, Wim E. 
245 1 0 |a Behavioral Genetics of the Mouse :  |b Volume 1, Genetics of Behavioral Phenotypes. 
264 1 |a New York :  |b Cambridge University Press,  |c 2013. 
264 4 |c ©2013. 
300 |a 1 online resource (362 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
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490 1 |a Cambridge Handbooks in Behavioral Genetics 
505 0 |a Intro -- Contents -- Contributors -- Preface -- 1 Behavior genetics -- Behavior genetics -- Behavioral phenotypes -- Aims and purposes of behavior genetics -- How far have we come? -- Where are we going? -- 2 Natural neurobiology and behavior of the mouse -- Summary -- Introduction -- Natural constraints for behavioral phenotyping in genetically modified mice -- Ethology -- Neural output -- Hippocampus of mice and men -- Ecological constraints -- Studying behavior and survival of mice in outdoor settings -- Principles -- Short-term survival of normal inbred strains -- Long-term selection of hippocampal mossy fiber traits and associated behavior -- Background -- Breeding a founder generation and observing natural selection -- Hippocampal malfunction in naturalistic environments -- Hippocampal lesions and naturalistic behavior of rodents -- Hippocampal lesions and malfunction in naturalistic environments -- Conclusions and outlook -- Ethological and ecological constraints -- Benefits of outdoor testing -- Concerns about outdoor testing of genetically modified mice -- Acknowledgments -- References -- 3 Ethogram of the mouse -- Introduction -- Ethogram of the mouse -- Single mouse in an unfamiliar new environment -- Two unfamiliar male mice in an unfamiliar environment -- A male and a female mouse together -- Adult mouse with pups -- Examples of the experimental use of the ethogram -- Future of the ethogram: computer vision and other high-tech applications -- References -- 4 Replicability and reliability of behavioral tests -- Introduction -- Replicability -- Fixed or random effects -- Enhancing replicability -- Replicability is not the ultimate good -- Reliability -- Test-retest reliability -- Critical choice of a subject population -- Boosting reliability by using more trials or longer trials -- Internal consistency for dynamic characteristics. 
505 8 |a Limitations of a single indicator of reliability and the need for thorough analysis of data -- Outliers can inflate consistency scores -- Conclusions -- Acknowledgments -- Appendix -- Mice -- Open field -- Y-maze -- Water escape -- Eating test -- Elevated plus maze -- Accelerating rotarod -- Grid test -- References -- 5 Audition -- Introduction -- Mouse models -- Hearing loss -- Age considerations -- ASR and PPI -- Acoustic startle response -- Prepulse inhibition -- Experiments with F1 hybrids and backcrosses -- Fear-potentiated startle -- Other approaches -- Psychophysical measurements using associative conditioning -- Observation of natural behaviors in response to sounds -- Physiological methods -- Anatomical methods -- Research approaches -- Acknowledgments -- References -- 6 Behavioral measurement of mouse visual function -- Introduction -- Why measure visual behavior? -- Considerations when testing mouse vision -- Testing methodologies: measures of visual perception in reinforcement-based tasks -- Testing methodologies: measures of automated visual responses -- Distinct vision-testing methodologies -- Practical application of mouse visual behavior -- References -- 7 Tactile system and nociception -- Introduction -- Individual differences -- Pain genes -- Measuring nociception in the mouse -- Heritability of nociception: mouse studies -- Pain phenomics in the mouse -- Qualitative strain differences -- Genetic mediation of nociception -- Genetic mediation of analgesia -- Genetic mediation of pruritis -- Sex × genotype interactions -- Pain genes: results of linkage mapping studies -- Thermal nociception QTLs -- Chemical/inflammatory nociception QTLs -- Neuropathic pain QTLs -- Analgesia QTLs -- References -- 8 Olfactory acuity in Mus musculus -- Methodology -- Buried food test -- Habituation-dishabituation -- Conditioned digging task. 
505 8 |a Conditioned avoidance learning -- Electroolfactogram -- Operant-olfactometry -- Odor detection thresholds -- Specific anosmias -- Mediating factors -- Age -- Sex -- Hormonal status -- Previous experience -- Trigeminal detection -- Conclusions -- Acknowledgments -- References -- 9 Taste genetics -- Introduction: taste is a complex trait -- Summary of the taste system -- Bitter taste genetics -- Sweet and umami taste genetics -- Salt and sour taste -- Taste and other complex phenotypes -- Conclusions -- References -- 10 Motor coordination in inbred mouse strains and the crucial role of the cerebellum -- Testing methods -- Inbred mouse strains -- Motor performance of inbred mouse strains -- Stationary beam -- Vertical grid -- Suspended wire or coat-hanger -- Rotorod -- Natural mutants with atrophy of the cerebelum -- Neuropathology -- Selective degeneration of cerebellar cortex -- Spinocerebellar degeneration -- Motor performance -- Stationary beam -- Vertical grid -- Suspended wire or coat-hanger -- Rotorod -- Acknowledgments -- References -- 11 Reflex development -- Introduction: about reflexology and innateness -- Basic considerations when studying early behavioral development of mice -- Changes in pup development due to the behavior of the dam -- Cross-fostering, in-fostering and un-fostering -- Litter culling -- Sex ratio in the litter -- Behavioral development of the mouse as assessed through test batteries -- Suckling test -- Patterns of ultrasonic emissions -- Genetic factors affecting reflex development -- Final considerations -- Acknowledgments -- References -- 12 Feeding and drinking -- Salts -- Bitter tastants -- Saccharin -- Sucrose -- Ethanol -- Glutamate/umami -- Fat intake and obesity-prone and obesity-resistant animals -- Recent strain survey studies from our laboratory -- Baseline food, water, and weight responses -- Sucrose. 
505 8 |a Fat (Intralipid) -- Glucoprivic and lipoprivic responses -- Conclusions -- Acknowledgments -- References -- 13 Getting it right -- Introduction -- Historical overview of mouse hand preference -- What does the behavior look like in the unbiased world? -- Associations of other developmental traits with paw preference -- Genetic analysis reveals complexity in paw preference -- Biased testing chambers reveal a process of learning and memory -- Phenotypic reaction norms and the genetic objective -- Retesting in oppositely biased worlds reveals learning and memory -- Genetically dominant and recessive forms of constitutive hand preference -- Key elements of the learning and memory process in hand preference -- Consolidation of memory in response to elapsed time after L-world training -- Anisomycin blocks consolidation of memory -- Retention of memory and dynamics of the learning process -- Rate of learning and limit of learning -- Genetic factors influence capacity and ability to learn hand preference -- Differences among strains with conditional behavior -- Resolution of dominant and recessive constitutive hand preference -- Independence of capacity and ability parameters -- Stochastic agent-based simulation of hand-preference behavior -- Challenging questions and persistent loose ends -- Hand-preference patterns are predicted emergent properties -- Research problem, the genetic task, and the biological question -- Instructive value of the mouse - the replicated individual -- Directional asymmetry - a "left-shift" or "right-shift" -- Physical variation in brain structure - cause or coincidence? -- Conclusions -- Acknowledgments -- References -- 14 Rhythms and sleep -- Preface -- Introduction -- Historical perspective -- Biological clocks concepts, mechanisms, and relevance -- Photoperiodism and seasonal rhythms -- Circadian regulation of sleep. 
505 8 |a Behavioral genetic studies of biological rhythms in mice -- Circadian period for locomotor activity -- Phase response -- Aschoffs rule -- Phase of circadian locomotor activity rhythms -- Amplitude of circadian locomotor rhythms -- Sleep -- Food entrainable rhythms -- Methamphetamine-sensitive circadian oscillator -- Development and aging -- CS inbred mice: an anomalous strain with rhythm splitting and long period -- Body temperature and thermoregulation -- Ingestive behaviors: food and water consumption -- Ethanol metabolism -- Photoperiodism and seasonal rhythms -- Notes on methods -- Illumination levels -- Reverse photoperiods -- Temporal responses to artificial selection -- Cage enrichment -- Quantitative genetic background in transgenic and congenic lines -- Summary of QTL data -- General conclusions -- References -- 15 The genetics of exploratory behavior -- Introduction -- Procedures -- Defining exploration -- Genetics: selection studies -- Genetics: strain comparisons -- Genetics: studies of genetic architecture -- Genetics: genetic correlations -- Localizing the genes -- Single-gene studies -- Mapping studies -- Conclusions -- Acknowledgments -- References -- 16 Strains, SNPs, and selected lines -- Introduction -- Naturalistic approach to the study of murine fear and anxiety in the laboratory -- Using between-strain differences to identify genetic factors underlying anxiety -- Using within-strain differences to identify genetic factors underlying anxiety -- Conclusions -- Acknowledgments -- References -- 17 Genetic influences on infant mouse ultrasonic vocalizations -- Introduction -- Ethology of ultrasonic calls -- Measures of ultrasonic calls -- Previous reviews of ultrasonic vocalization studies -- Genetic influences on ultrasonic calls of infant mice -- Background -- Strain comparison -- Cross-breeding studies -- Selection studies. 
505 8 |a Mendelian crosses and other methods which examine the effects of single genes. 
520 |a A comprehensive review of the current state of our knowledge on the inheritance of normal behaviour in the laboratory mouse. 
588 |a Description based on publisher supplied metadata and other sources. 
590 |a Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2021. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.  
650 0 |a Mice -- Genetics.. 
650 0 |a Behavior genetics. 
655 4 |a Electronic books. 
700 1 |a Sluyter, Frans. 
700 1 |a Gerlai, Robert T. 
700 1 |a Pietropaolo, Susanna. 
776 0 8 |i Print version:  |a Crusio, Wim E.  |t Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes  |d New York : Cambridge University Press,c2013  |z 9781107034815 
797 2 |a ProQuest (Firm) 
830 0 |a Cambridge Handbooks in Behavioral Genetics 
856 4 0 |u https://ebookcentral.proquest.com/lib/suleyman-ebooks/detail.action?docID=1139743  |z Click to View