Behavioral Genetics of the Mouse : Volume 1, Genetics of Behavioral Phenotypes.

A comprehensive review of the current state of our knowledge on the inheritance of normal behaviour in the laboratory mouse.

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Bibliographic Details
Main Author: Crusio, Wim E.
Other Authors: Sluyter, Frans., Gerlai, Robert T., Pietropaolo, Susanna.
Format: eBook
Language:English
Published: New York : Cambridge University Press, 2013.
Series:Cambridge Handbooks in Behavioral Genetics
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Online Access:Click to View
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Table of Contents:
  • Intro
  • Contents
  • Contributors
  • Preface
  • 1 Behavior genetics
  • Behavior genetics
  • Behavioral phenotypes
  • Aims and purposes of behavior genetics
  • How far have we come?
  • Where are we going?
  • 2 Natural neurobiology and behavior of the mouse
  • Summary
  • Introduction
  • Natural constraints for behavioral phenotyping in genetically modified mice
  • Ethology
  • Neural output
  • Hippocampus of mice and men
  • Ecological constraints
  • Studying behavior and survival of mice in outdoor settings
  • Principles
  • Short-term survival of normal inbred strains
  • Long-term selection of hippocampal mossy fiber traits and associated behavior
  • Background
  • Breeding a founder generation and observing natural selection
  • Hippocampal malfunction in naturalistic environments
  • Hippocampal lesions and naturalistic behavior of rodents
  • Hippocampal lesions and malfunction in naturalistic environments
  • Conclusions and outlook
  • Ethological and ecological constraints
  • Benefits of outdoor testing
  • Concerns about outdoor testing of genetically modified mice
  • Acknowledgments
  • References
  • 3 Ethogram of the mouse
  • Introduction
  • Ethogram of the mouse
  • Single mouse in an unfamiliar new environment
  • Two unfamiliar male mice in an unfamiliar environment
  • A male and a female mouse together
  • Adult mouse with pups
  • Examples of the experimental use of the ethogram
  • Future of the ethogram: computer vision and other high-tech applications
  • References
  • 4 Replicability and reliability of behavioral tests
  • Introduction
  • Replicability
  • Fixed or random effects
  • Enhancing replicability
  • Replicability is not the ultimate good
  • Reliability
  • Test-retest reliability
  • Critical choice of a subject population
  • Boosting reliability by using more trials or longer trials
  • Internal consistency for dynamic characteristics.
  • Limitations of a single indicator of reliability and the need for thorough analysis of data
  • Outliers can inflate consistency scores
  • Conclusions
  • Acknowledgments
  • Appendix
  • Mice
  • Open field
  • Y-maze
  • Water escape
  • Eating test
  • Elevated plus maze
  • Accelerating rotarod
  • Grid test
  • References
  • 5 Audition
  • Introduction
  • Mouse models
  • Hearing loss
  • Age considerations
  • ASR and PPI
  • Acoustic startle response
  • Prepulse inhibition
  • Experiments with F1 hybrids and backcrosses
  • Fear-potentiated startle
  • Other approaches
  • Psychophysical measurements using associative conditioning
  • Observation of natural behaviors in response to sounds
  • Physiological methods
  • Anatomical methods
  • Research approaches
  • Acknowledgments
  • References
  • 6 Behavioral measurement of mouse visual function
  • Introduction
  • Why measure visual behavior?
  • Considerations when testing mouse vision
  • Testing methodologies: measures of visual perception in reinforcement-based tasks
  • Testing methodologies: measures of automated visual responses
  • Distinct vision-testing methodologies
  • Practical application of mouse visual behavior
  • References
  • 7 Tactile system and nociception
  • Introduction
  • Individual differences
  • Pain genes
  • Measuring nociception in the mouse
  • Heritability of nociception: mouse studies
  • Pain phenomics in the mouse
  • Qualitative strain differences
  • Genetic mediation of nociception
  • Genetic mediation of analgesia
  • Genetic mediation of pruritis
  • Sex × genotype interactions
  • Pain genes: results of linkage mapping studies
  • Thermal nociception QTLs
  • Chemical/inflammatory nociception QTLs
  • Neuropathic pain QTLs
  • Analgesia QTLs
  • References
  • 8 Olfactory acuity in Mus musculus
  • Methodology
  • Buried food test
  • Habituation-dishabituation
  • Conditioned digging task.
  • Conditioned avoidance learning
  • Electroolfactogram
  • Operant-olfactometry
  • Odor detection thresholds
  • Specific anosmias
  • Mediating factors
  • Age
  • Sex
  • Hormonal status
  • Previous experience
  • Trigeminal detection
  • Conclusions
  • Acknowledgments
  • References
  • 9 Taste genetics
  • Introduction: taste is a complex trait
  • Summary of the taste system
  • Bitter taste genetics
  • Sweet and umami taste genetics
  • Salt and sour taste
  • Taste and other complex phenotypes
  • Conclusions
  • References
  • 10 Motor coordination in inbred mouse strains and the crucial role of the cerebellum
  • Testing methods
  • Inbred mouse strains
  • Motor performance of inbred mouse strains
  • Stationary beam
  • Vertical grid
  • Suspended wire or coat-hanger
  • Rotorod
  • Natural mutants with atrophy of the cerebelum
  • Neuropathology
  • Selective degeneration of cerebellar cortex
  • Spinocerebellar degeneration
  • Motor performance
  • Stationary beam
  • Vertical grid
  • Suspended wire or coat-hanger
  • Rotorod
  • Acknowledgments
  • References
  • 11 Reflex development
  • Introduction: about reflexology and innateness
  • Basic considerations when studying early behavioral development of mice
  • Changes in pup development due to the behavior of the dam
  • Cross-fostering, in-fostering and un-fostering
  • Litter culling
  • Sex ratio in the litter
  • Behavioral development of the mouse as assessed through test batteries
  • Suckling test
  • Patterns of ultrasonic emissions
  • Genetic factors affecting reflex development
  • Final considerations
  • Acknowledgments
  • References
  • 12 Feeding and drinking
  • Salts
  • Bitter tastants
  • Saccharin
  • Sucrose
  • Ethanol
  • Glutamate/umami
  • Fat intake and obesity-prone and obesity-resistant animals
  • Recent strain survey studies from our laboratory
  • Baseline food, water, and weight responses
  • Sucrose.
  • Fat (Intralipid)
  • Glucoprivic and lipoprivic responses
  • Conclusions
  • Acknowledgments
  • References
  • 13 Getting it right
  • Introduction
  • Historical overview of mouse hand preference
  • What does the behavior look like in the unbiased world?
  • Associations of other developmental traits with paw preference
  • Genetic analysis reveals complexity in paw preference
  • Biased testing chambers reveal a process of learning and memory
  • Phenotypic reaction norms and the genetic objective
  • Retesting in oppositely biased worlds reveals learning and memory
  • Genetically dominant and recessive forms of constitutive hand preference
  • Key elements of the learning and memory process in hand preference
  • Consolidation of memory in response to elapsed time after L-world training
  • Anisomycin blocks consolidation of memory
  • Retention of memory and dynamics of the learning process
  • Rate of learning and limit of learning
  • Genetic factors influence capacity and ability to learn hand preference
  • Differences among strains with conditional behavior
  • Resolution of dominant and recessive constitutive hand preference
  • Independence of capacity and ability parameters
  • Stochastic agent-based simulation of hand-preference behavior
  • Challenging questions and persistent loose ends
  • Hand-preference patterns are predicted emergent properties
  • Research problem, the genetic task, and the biological question
  • Instructive value of the mouse - the replicated individual
  • Directional asymmetry - a "left-shift" or "right-shift"
  • Physical variation in brain structure - cause or coincidence?
  • Conclusions
  • Acknowledgments
  • References
  • 14 Rhythms and sleep
  • Preface
  • Introduction
  • Historical perspective
  • Biological clocks concepts, mechanisms, and relevance
  • Photoperiodism and seasonal rhythms
  • Circadian regulation of sleep.
  • Behavioral genetic studies of biological rhythms in mice
  • Circadian period for locomotor activity
  • Phase response
  • Aschoffs rule
  • Phase of circadian locomotor activity rhythms
  • Amplitude of circadian locomotor rhythms
  • Sleep
  • Food entrainable rhythms
  • Methamphetamine-sensitive circadian oscillator
  • Development and aging
  • CS inbred mice: an anomalous strain with rhythm splitting and long period
  • Body temperature and thermoregulation
  • Ingestive behaviors: food and water consumption
  • Ethanol metabolism
  • Photoperiodism and seasonal rhythms
  • Notes on methods
  • Illumination levels
  • Reverse photoperiods
  • Temporal responses to artificial selection
  • Cage enrichment
  • Quantitative genetic background in transgenic and congenic lines
  • Summary of QTL data
  • General conclusions
  • References
  • 15 The genetics of exploratory behavior
  • Introduction
  • Procedures
  • Defining exploration
  • Genetics: selection studies
  • Genetics: strain comparisons
  • Genetics: studies of genetic architecture
  • Genetics: genetic correlations
  • Localizing the genes
  • Single-gene studies
  • Mapping studies
  • Conclusions
  • Acknowledgments
  • References
  • 16 Strains, SNPs, and selected lines
  • Introduction
  • Naturalistic approach to the study of murine fear and anxiety in the laboratory
  • Using between-strain differences to identify genetic factors underlying anxiety
  • Using within-strain differences to identify genetic factors underlying anxiety
  • Conclusions
  • Acknowledgments
  • References
  • 17 Genetic influences on infant mouse ultrasonic vocalizations
  • Introduction
  • Ethology of ultrasonic calls
  • Measures of ultrasonic calls
  • Previous reviews of ultrasonic vocalization studies
  • Genetic influences on ultrasonic calls of infant mice
  • Background
  • Strain comparison
  • Cross-breeding studies
  • Selection studies.
  • Mendelian crosses and other methods which examine the effects of single genes.