Mouse In Animal Genetics And Breeding Research, The.

The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics re...

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Bibliographic Details
Main Author: Eisen, Eugene J.
Format: eBook
Language:English
Published: Singapore : World Scientific Publishing Company, 2005.
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Table of Contents:
  • Intro
  • TABLE OF CONTENTS
  • PREFACE
  • CHAPTER 1 THE BEGINNINGS: ODE TO A WEE MOUSE
  • 1. Introduction
  • 2. Mouse Domestication
  • 3. The Birth of Mouse Genetics
  • 4. Conclusions
  • References
  • CHAPTER 2 TESTING QUANTITATIVE GENETIC SELECTION THEORY
  • 1. Introduction
  • 2. Predicted and Realized Heritabilities
  • 3. Predicted and Realized Genetic Correlations
  • 4. Variation Among Replicates
  • 5. Response to Index Selection
  • 6. Individual Selection Compared to Other Methods
  • 7. Long-term Responses and Selection Limits
  • 8. Testing Validity of the Infinitesimal Model
  • 9. Conclusions
  • References
  • CHAPTER 3 MATERNAL EFFECTS, GENOMIC IMPRINTING AND EVOLUTION
  • 1. Introduction
  • 2. Temporal Aspects of Maternal Effects
  • 3. Effects of Maternal Age
  • 4. Effects of Maternal Nutrition
  • 5. Prenatal Maternal Effects
  • 5.1. Effects of Litter Attributes
  • 5.2. Effects of Prenatal Toxin Exposure
  • 6. Postnatal Maternal Effects
  • 6.1. Effect of Lactation
  • 6.2. Effect of Maternal Care
  • 7. Maternal Effects and Role in Selection
  • 8. Maternal Effects and Familial Relationships
  • 9. Maternal Effects Across Multiple Generations
  • 10. Maternal Effects and Interactions with Other Epigenetic Phenomena
  • 10.1. Maternal Effects and Its Effect on Genomic Imprinting
  • 10.2. Genomic Imprinting and Its Effect on Maternal Effects
  • 11. Evolution of Maternal Effects and Genomic Imprinting
  • 12. Conclusion
  • Acknowledgements
  • References
  • CHAPTER 4 INBREEDING AND CROSSBREEDING
  • 1. What is Inbreeding?
  • 1.1. Definition of Inbreeding
  • 1.2. History of Inbreeding
  • 1.3. Advantages of Inbreeding
  • 1.4. Limitations of Inbreeding
  • 2. Generation of Mouse Inbred Strains
  • 2.1. General Inbreeding Procedure
  • 2.2. Inbreeding of Wild-Derived Mice
  • 2.3. Inbreeding of Selected Strains
  • 3. Widely Used Mouse Inbred Strains.
  • 3.1. Genetic Diversity
  • 3.2. Phenotypic Diversity
  • 4. Deviations from Common Inbred Strains
  • 4.1. Substrains of Inbred Strains
  • 4.2. Coisogenic Strains
  • 4.3. Balancer Chromosome Strains
  • 5. Crossbreeding
  • 5.1. Crossbreds
  • 5.2. Mapping Populations
  • 5.3. Fine Mapping Populations
  • 6. Inbred Strains Generated from Crossbred Populations
  • 6.1. Congenic Strains
  • 6.2. Recombinant Congenic Strains
  • 6.3. Recombinant Inbred Strains
  • 6.4. Chromosome Substitution Strains
  • 6.5. Conplastic Strains
  • 7. Future Prospects for Inbreeding and Crossbreeding
  • References
  • CHAPTER 5 GENOTYPE BY ENVIRONMENT INTERACTION: LESSONS FROM THE MOUSE
  • 1. Introduction
  • 2. Genotypes, Environments and Genotype by Environment Interaction Defined
  • 3. Experimental and Analytical Methods to Study GEI
  • 3.1. Analysis of Variance
  • 3.2. Genetic Correlation
  • 3.3. Reaction Norm
  • 4. Interactions of Genotype with the External Environment
  • 4.1. Laboratory Environment and Handling
  • 4.2. Thermal Environment
  • 4.3. Habitat
  • 4.4. Nutrition
  • 4.5. Toxins and Drugs
  • 5. Interactions of Genotype with the Internal Environment
  • 5.1. Sex
  • 5.2. Age
  • 5.3. Physiological State
  • 6. Mating System by Environment Interactions
  • 6.1. Inbreeding Depression and the Environment
  • 6.2. Response of Inbred versus Outbred Individuals to the Environment
  • 6.3. Impact of the Environment on Heterosis
  • 7. The Environment for Selection
  • 8. Conclusions
  • References
  • CHAPTER 6 GENETICS OF GROWTH IN THE MOUSE
  • 1. Introduction
  • 2. Mouse Growth Pattern
  • 3. Physiology of Growth
  • 4. Longitudinal Study of Growth
  • 5. Quantitative Genetics of Growth
  • 6. Quantitative Trait Loci (QTL) Affecting Growth
  • 7. Spontaneous Mutants and Transgenic Models
  • 8. Conclusions
  • References
  • CHAPTER 7 GENETICS OF BODY COMPOSITION AND METABOLIC RATE.
  • 1. Introduction
  • 1.1. Obesity in Humans
  • 1.2. Fatness in Farm Animals
  • 1.3. Relationships Between Body Composition and Metabolic Rate
  • 1.4. Body Weight and Body Composition in Normal Mice
  • 2. Measurement of Body Composition and Metabolic Rate in Mice
  • 3. Genetic Basis of Obesity
  • 3.1. Effects of Single Gene Mutations on Fatness
  • 3.2. Candidate Gene Approaches
  • 3.3. QTL for Fatness
  • 3.4. Polygenie Inheritance of Fatness
  • 3.5. Correlated Effects of Growth Selection on Fatness
  • 3.6. Importance of Fat Distribution
  • 4. Genetic Basis of Metabolic Rate
  • 5. Conclusions
  • Acknowledgements
  • References
  • CHAPTER 8 GENETICS OF REPRODUCTION
  • 1. Introduction
  • 2. Direct Selection for Larger Litter Size
  • 3. Direct Selection for Smaller Litter Size
  • 4. Selection for Components of Litter Size
  • 5. Selection for Testes Mass
  • 6. Selection for Multiple-Parity Litter Size
  • 7. Response in Lifetime Reproduction from First-Parity Selection
  • 8. Limits Observed in Selection for Litter Size
  • 9. Elaboration on Responses in the Nebraska Selection
  • 10. Modeling Litter Size
  • 11. Litter Size and Body Weight Correlation
  • 12. Heterosis in Line Crosses
  • 13. Inbreeding Depression
  • 14. Conception Rate and Fertility
  • 15. Conclusions
  • References
  • CHAPTER 9 GENETICS AND BEHAVIOR
  • 1. Introduction
  • 2. WebQTL and Behavioral Phenotypes
  • 3. Inbred Strains and Behavior
  • 4. Genes and Phenotypic Complexity
  • 5. QTL Analysis and Behavior - The Problem
  • 6. QTL Analysis and Behavior - Some Solutions
  • 7. Conclusions
  • Acknowledgements
  • References
  • CHAPTER 10 GENETICS OF DISEASE RESISTANCE
  • 1. Introduction
  • 2. Utility of Mouse Models
  • 3. The Genetics of Resistance to Pathogens
  • 3.1. The Major Histocompatibility Complex Affects Resistance to Microbes
  • 3.2. Host Resistance to Parasitic Infection.
  • 3.3. The Genetics of Prion Disease Susceptibility
  • 4. The Genetics of Noninfectious Inflammatory Diseases
  • 4.1. Common Features of Autoimmunity and Allergy
  • 4.2. The Genetics of Autoimmunity
  • 4.3. Genetic Susceptibility to Allergy and Asthma
  • 5. Conclusions
  • References
  • CHAPTER 11 GENOMIC DISSECTION OF COMPLEX TRAIT PREDISPOSITION
  • 1. Introduction
  • 2. Significance
  • 3. Background
  • 4. Quantitative Genomics: A New Experimental Paradigm for Analysis of Complex Trait Genetics
  • 5. Expected Outcomes from the Transcriptome Mapping Paradigm
  • 6. Future Directions for Transcriptome Mapping
  • 7. Statistical Issues in Transcriptome Mapping
  • 8. Implementation of Transcriptome Mapping to Study Obesity
  • 9. Limitations of Transcriptome Mapping
  • 10. New Frontiers for Analysis of Complex Trait Genetics
  • Acknowledgments
  • References
  • CHAPTER 12 MOUSE MUTAGENESIS
  • 1. Introduction
  • 2. ENU Mutagenesis: History
  • 3. ENU Mutagenesis: Practical Aspects
  • 3.1. Treatment Protocols
  • 3.2. Husbandry
  • 3.3. Screening Assays
  • 3.4. Heritability Testing
  • 3.5. Locus Mapping
  • 3.6. Mutation Identification
  • 3.7. Proof of Causality
  • 4. Alternative Mutagenesis Techniques
  • 5. Genotype-Driven Mutagenesis
  • 6. Conclusions
  • References
  • CHAPTER 13 EMBRYO BIOTECHNOLOGIES
  • 1. Introduction
  • 2. Embryo Techniques
  • 2.1. Superovulation and Generation of Ova
  • 2.2. Embryo Culture, IVF and Zona Disruption
  • 2.3. Chimera Development
  • 2.4. Intracytoplasmic Sperm Injection (ICSI)
  • 2.5. Embryo Transfer
  • 3. Assisted Reproductive Technologies and Embryo Engineering
  • 3.1. Nuclear Transfer (NT)
  • 3.2. Microinjection
  • 3.3. Retrovirus-Mediated Gene Transfer
  • 3.4. ES Cell Transfer
  • 3.5. Primordial Germ Cell Technologies
  • 3.6. Germ Cells as Vectors
  • 3.7. Mitochondrial Transfer into Preimplantation Ova.
  • 3.8. Embryo Cryopreservation
  • 4. Future of Embryo Biotechnologies
  • Acknowledgements
  • References
  • CHAPTER 14 TRANSGENICS
  • 1. Introduction
  • 2. Genetic Engineering Methods
  • 2.1. Pronuclear Microinjection
  • 2.2. Viral Vectors
  • 2.3. Spermatogonial Cell and Sperm-Mediated Gene Transfer
  • 2.4. Embryonic Stem Cell-Mediated Gene Transfer
  • 3. Homologous Recombination or "Knockouts"
  • 4. Strain Considerations
  • 5. Integration of a Transgene into a Breeding Population
  • 6. Conclusions
  • References
  • CHAPTER 15 THE MOUSE IN BIOMEDICAL RESEARCH
  • 1. Introduction
  • 2. Tissue Transplantation
  • 3. Immunology
  • 4. Tumor Biology
  • 5. Cardiovascular Biology
  • 6. Birth Defects
  • 7. Infectious Diseases
  • 8. Neurological Diseases
  • 9. Conclusions
  • References
  • CHAPTER 16 THE MOUSE GENOME SEQUENCING PROJECT: AN OVERVIEW
  • 1. Introduction
  • 2. Genome Sequencing and Assembly: An Evolving Process
  • 3. Designing the Mouse Project
  • 4. Sequencing and Assembling the Mouse Genome
  • 5. The Mouse Project Legacy
  • 6. Conclusions
  • References
  • Index.